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ʱ:2017-11-06 21:18Դ:δ֪ :yong :
2017830 Ѷ /BIOON/ --ΪҴEKֵIJѧоԼصƷоչϣܹϲ 1. ͿҩܹЧEKֵ EKһĴʹԼƣߵ
2017830 Ѷ /BIOON/ --ΪҴEKֵIJѧоԼصƷоչϣܹϲ
 
 
1. ͿҩܹЧEKֵ
 
 
EKһĴʹԼƣߵĴʱȻ̡ܶEKһ"EKָϸ"ȺƵԼĸҪá
 
UABIchiro NakanoʿMaode Wangʿ˺EKָϸάֵͷӻơһ߷͵ԷƼܹEKֵƾDZڵЧ
 
ȣ߷һOTS167ҩڶԵİ֢ٴЧ룬ǼƻоEKֶԸҩԵڻơ߷EKܵOTS167֮һͷӰе-NEK2ͨCMP3aNEK2EKֵܹõƣҸƷϷܹ𵽸ѵɱЧ
 
NEK2һǰоٵļøףоǷNEK2EKָϸеıϴ󣬶NEK2EKֵʮҪСģͽҲõ׶ϸʮֹؼ
 
ͨһϵе飬оǷNEK2ٽϸԼԲĻƣǷNEK2ܹһEZH2İ鵰׼׻תøϣӶEZH2⣬ϸҸԼ
 
ǰоѾEH2ڶ఩֢нϸߵıͬʱEZH2߻ԼЧ½
 
һٴУ߷NEK2ıEZH2ڽܵĹҲ뻼ߵĽˮƽԡHEK2ڸİϸбᷢϵˣΪNEK2һҪάEKָϸȶԵӣԵƼCMP3aԳΪDZڵҩ
 
 
2. Sci Trans MedCAR-TƷEKΪʲôЧѣ
 
Doi.scitranslmed.aaa0984
 
 
һٴŴεTϸEKֵЧȻҪչһ֢Ҫ΢еЧӦԼͻĸԡؽһڵġScience Translational Medicine־ϡ
 
ȥԱϦǴѧҽѧԺоDZCAR-TƷEKֵٴðԿԭEGFRvIIICARTԻ߽ơµһоУ߷˸üƿһǻ֯EGFRvIIIıԽϴ΢нǿЧӦһЧӦƹлءˣΪҪͬʱѰµԭԼѰҿ˷ЧӦҩӶʵֶ֯ɱˡ
 
"һ׶εٴ飬ϣϸܹ˳ֳ֯ҽͶԻߵĶԡܹʵ֣ôΪѡƷ֮һ"µO'Rourkeʿ˵
 
ÿ22000˱ϻEK֣нǿҩԣһи఩֢Ļͨᳬ15¡
 
о߷Ϊ飬һڽCARTϸעƺûٴνڶƺʱƺʱϸע֮ڣܹ⵽CART- EGFRvIIIϸ֯нһܹѪҺ֯м⵽ϸϸעҷƽȵ½һ¹ڼˮƽ
 
⣬߷CARTϸ߼ܵĵڣаźͨ·Եϵ"ϸע֮֯лTϸĴֳζҪ΢ʹ֮CARTΪѺ"
 
 
3. EKѪ֮ڹ?
 
 
Ѫǻ֢ķйءȻо֣ԲEK򲡺͸ѪȺвڣһоʼʾ֮ڵ־˵ϵоԱʵѪˮƽɺܴӰ
 
оСijԱԸײѧOSUоԱǽоɹڡѧ桷־ϡ
 
ͬһߣѧвѧJudith Schwartzbaum˵"򲡺Ѫˮƽ߻ʹ弸λ֢ķӣ᳦ٰͰװȡ"
 
ȻEKֵԲ˵ȫһˡ෴"ЩĶԲѪˮƽȺЩѪǻȺ"
 
EKĴ֮һռԭԲķ֮һռжķ֮
 
EKԴڴ񾭽ϸ񾭽ϸԪ񾭹صĵźţ෴𵽱άֺ֧Ԫá
 
EKͨ෢ȺȷΪĸϸijEK֣Ļƽֻ14¡
 
оСEKְȷǰһʱѪˮƽݣԼEKֺϵԽ˷
 
ѪȺ򲡻߲׷EK֡⣬֮ڵֹڻȷǰһǿġ
 
Schwartzbaum˵һʹǵоŶӰ˼⣬"ΪʲôѪˮƽĹϵֶ෴"
 
ҲһЩܵؽۣܰһЩ
 
磬ӰѪˮƽ磬֪ȵEKָйأ򲡻ָ߳ļҪȷ򲡻һЩ
 
һֽͿԴڴԶǵʹáȻԽռص2%ȴҪĴԼ20%Ŀǣ"Schwartzbaum˵
 
ЩⶼдһоѪˮƽԲ֮ڵĹǷԲ·
 
 
4. Int J Radiat OncolEKƻùĵ½չ
 
 
ȷﻼжڲ˼ѶһԵĴΪְ֢ܲƷӦãEKԵȷܶʱ︴չϳEKֵIJ˲Ŀǰı׼ƷƵλڽΪ16¡
 
ڻƻо󼪶ѧģMUHCоС鿪һǿEKЧ·ɹλӳ22£ΪEKֵIJ˴ϣٴ2International Journal of Radiology Oncologyϡ
 
"EKַdzΡ"о쵼ߡMUHCҽʦGeorge Shenouda˵"Ѹͣܿ촫ԣʹͨȫг֯dzѡ"
 
EKֵı׼Ʒͨгܶ֯÷ϻµ֯ҪϢ4-5ܲܽзơҵʱİϸҵǣİϸϸܷƺͻơ
 
ǵ·УоԱڷ֮ǰ벡˻ƣҲ¸ơ¸ƿԷֹڲ˿ڼչӳ˵ڡ
 
¸֮󣬲˻ܼٷơ"ͨڸ̵ʱ䡢СƵʸͬķܹõؿЧƻϸЩϸǰ֢ĻƵʽ1/3Ҳ˲˵ĸ⣬ζƷýͲ١"Shenoudaʿ˵
 
ܻҪһоЩ˹衣"о50%IJʱѾ2꣬ǷdzĵģǶЩеܸˡ"Shenoudaʿ˵
 
 
5. CellWNT5AEKָϸֻΪƤϸϸ
 
doi:10.1016/j.cell.2016.10.039
 
 
Խĸϸglioblastoma multiformeȻΪĸ߶Ե԰ĸһµоУݴѧMDɭ֢ĵоԱһϸڴϮԵɢĹ̡о20161117CellڿϣıΪ"Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth"
 
ĹͬһBaoli Huʿ˵"ܽƳƺͻƵǿƣĸϸϲԤձڵĸǵоڰĸϸڴϮԵĻƣDZһµƲԡ"
 
HuͬǿһֽĸϸģȷEKָϸλãEKָϸеĸϸܹİϸǽһֻWNT5AʱEKָϸת䣬Ӷ½
 
Hu˵"ǷܵWNT5AڵEKָϸƤϸϸendothelial-like cellЩµıGdECϸļִƤϸӶγһ֧ԶԭĽEKϸ΢⾭ᵼDzͼ"
 
ٴ֤ݽʾԭWNT5AЩDz͸оиߵıˮƽGdECҲиߵ֤ʵWNT5A鵼EKָϸֻEKϸɢڹӶְ֢dz
 
оȷWNT5AEKָϸתΪGdECзһֹؼԵáΪһµƽĸϸ˵IJṩܡ
 
ڵٴݱΪԽĸϸһҩõFDA׼ҩﱴbevacizumabܹͨѪƤӣVEGFò˻洦
 
Hu˵"ǵijݱWNT5A鵼GdECִֻƤϸļļĸϸ˴δ֤ʵ洦µIJͨµͽԼӦƽܿVEGFƷ԰ߵƽ"
 
 
6. ذβƷɸ㶨EK֣
 
 
CLAоԱֽUCLAһʵƷFDA׼ƷһԼСEKֵĴС԰EKֵƷѽҺͻ״ϸ磨DCVƷʹ˲˵һԲ֯ĿǰϽ顣
 
ڶʵУоԱֽDCVֵϵͳͬҩһʹÿTϸЧEKϸֶҩֱһPD-1壨ٽڵTϸһPLX3397ʵҩԼڵЧӦ
 
EKdzһֶԲ֮һҲߵһֶݹƽ꽫12000˱ϳEK֣ʹĵЩ˵ʵ5%ͬʱְ֢ĿԺܸߣĿǰûԸı׼ƷоԱС˵֯но
 
оҲΪоԱָ˿EKּƷ·򡣣Bioon.com
 
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